Cf4 ionic or covalent

R4R30Plus: Meet fellow redditors over 30

2012.10.14 15:05 SurvivorType R4R30Plus: Meet fellow redditors over 30

Come in and meet people over 30! Whether you're looking for friends, partners, drinking buddies, or friends with benefits, this is the place on Reddit to find people over age 30 to meet in real life. You don't have to be 30 to be a member, but if you want to post you need to be 30+.

2009.02.26 20:08 Childfree

Discussion topics and links of interest to childfree individuals.

2008.04.14 21:57 Cats

Pictures, videos, questions, and articles featuring/about cats.




Welcome to DIORR’s guide to invoke deez (reroll targon invoker), the most egregious attrition comp to have come out of TFT in a while.
First, about myself: I am a fairly acceptable TFT player, having hit ~500lp in both set 8 and 8.5 (I think I could’ve pushed higher in 8.5 but I decayed, might be a cope though). You can find my lolchess here:


Now that that’s out of the way, let’s talk about why this comp is so gross and oppressive. Your core board will be: Ashe, Soraka, Galio, Taric, Lissandra, Shen, Sejuani. This comp takes advantage of the fact that targon provides healing and shielding bonuses which benefit most of your core units: Soraka, Galio, Taric, Shen, and Sejuani. Your board will become an unkillable overtime cringe machine that will have u streak all of stage 3/4 as well as into 5 until your opponents hit K’Sante. Freljord is a very strong in and of itself and is especially good with this comp, which we will talk about later.


This comp is fairly flexible for items, the only items you really want to avoid are bows and swords.
Component Priority: Tear >> Rod > Chain/Belt
Item Priorities:
Completed Item Tier List
Soraka: Shojin, Archangels (THESE ARE YOUR HIGHEST PRIORITY) > Deathcap >> Shiv/JG (JG only if at least 1 Archangels)
Galio/Taric: Tank items (redemption, vow, and warmogs are very good here), AP items
Lissandra: Ionic (lower priority)
The beauty of this comp is that your primary/secondary tanks are AP scaling/item choice, allowing you to greed tears for Soraka without getting punished for extra tears/rods, since you can use infinite tears with vow/redemption as well as put AP items on Galio and Taric. If you choose to go the AP itemization route on Galio/Taric (better on Galio due to healing) you need to have at least one belt item as well (ideally warmogs) to provide some base HP so your frontline doesn’t get assblasted before you have the chance to cast.
By nature of being an attrition comp, archangels is naturally the best choice for Soraka, especially as you both do damage and heal (making items such as JG, GS, gunblade less ideal, however still playable). Remember how we talked about Freljord being very good above? Archangels is the reason why; Freljord provides a lot of stall for Archangels to kick in. People talk about how Soraka is a fake unit etc, etc, but don’t realize that the scaling on Soraka is INSANE. She probably utilizes AA better than any other unit in the game and is secretly overtuned. Despite getting mana from invoker, shojin is still quite good on Soraka due to her high mana cap. Shiv is good on Soraka as well if you need to kill swords and bows, as the extra AS is nice with shojin and the magic shred not being bad.


Moving onto your legend, because you’re rolling for Soraka and Galio, as well as Taric (if healthy enough or naturaled enough), Lee Sin is the clear choice here. This is the only legend you should be taking.


In terms of region, the best by far is Ionia God-Willow’s Grove. It lets you cap your board higher by flexing more Freljord, Targon, 6 Invoker, etc, as well as making transitions in between trait intervals smoother. Targon Marus Omegnum is good for the same reason, but is not as strong mid game. Ionia Placidium Library is also very good, as the boost from 3 to 4 Freljord as well from 3 to 4 Targon (if space to fit Aphelios or have +1) provides A LOT of stall. Invoker spat is good for obvious reasons, all your units utilize mana very well and spat allows you to drop Cass/Karma.


Similarly, for augments, +1 for Freljord/InvokeTargon/Return on Investment are very good. Dedication is similarly good for hitting 6 invoker. Frequent flier is quite good, letting you roll for the Taric at a big discount as well as being good in a general sense for reroll comps. Infusion obviously is good. LOVING INVOCATION IS THE BEST AUGMENT IN THE GAME FOR OBVIOUS REASONS. IF YOU HIT THIS ITS GAME OVER. IF U SEE IT DONT EVEN LOOK AT THE OTHER CHOICES TAKE IT AND BUILD SORAKA INFINITE SHOJINS (by infinite I mean probably 2, 3 might have u spillover and lose EV). IF U NEED TO ASK WHY IDK WHAT TO TELL U. Winds of War looks LIT but I haven’t had the opportunity to try it yet. The typical reroll augments are clearly playable, no need to discuss that here.


Early Game: Early game is the weakest part of this comp, there aren’t many great 1* AP item holders. Viego/Cass/Kayle are likely the best item holders here, and you should be making use of your rerolls to build a stable frontline. If you can slam a shojin obviously you should probably be itemizing Viego or Cass instead of Kayle. THIS IS ESPECIALLY IMPORTANT AS YOU CAN NO LONGER FULL OPEN STAGE 2 DUE TO LEVELLING THRESHOLD CHANGES. BUILD AN ACCEPTABLE FRONTLINE. IF YOU NEED TO LOSE ECON TO MAKE A MAOKAI 2 OR A POPPY 2 THEN DO SO. Sunfire is a good slam here to preserve hp and can be put on Taric later. If by any chance your board is insane you can go for win streak here but more than likely this will not be possible because you're going to be playing reroll augment. Most times you will be trying to preserve hp while loss streaking into neutrals. Below is an example of a good early game board:
Example early game board
Early/Mid Game: Post-krugs is the most precarious spot. Flex players will have stronger boards, finding 2* 2 costs, as well as have more items where you will likely still have a your items on Viego/Poppy/Maokai/other 1 costs. You will likely be sacking a few stages more so you can roll on 6. At 3-3 level to 6 and send it down to 20 or so for the following core units: Galio/Soraka/Taric. If you hit an Ashe 2, feel free to play it, but you don't need to 3* Ashe since Ashe 3 is fake. Flex the rest of your slots on whatever strong frontline you're able to hit. Feel free to continue playing Poppy and Maokai if you 2* them. You can also continue to play Demacia for a while if you don't hit Soraka since the free item is very good on both Galio/Kayle. This lowroll line is a bit riskieweaker but is playable especially if you have a sunfire slammed. THE MOST IMPORTANT UNIT TO HIT HERE IS GALIO. ITEMIZED GALIO CRANKS. IF YOU HIT GALIO 2 AND SORAKA 2 YOU ARE BING CHILLING UNTIL NEUTRALS. Below is an example of a good mid/early board:
Example early/mid game board
Mid Game: Depending on how healthy you are, you can continue to play this board and econ up until neutrals or you can send it a little again. The ideal mid game board will include GALIO/SORAKA/TARIC/LISSANDRA/KARMA. From this spot until neutrals you should be slowrolling for Galio and Soraka. If played properly with acceptable items, you should winstreak until neutrals with itemized Galio and Soraka. Below is an example of a mid game board:
Example mid game board
Mid/Late Game: By 4-1, you should ideally have 5-6 Sorakas and Galios, as well as paired or 2* Taric/Lissandra. You can continue to slowroll at this point or dig a little to stabilize your board depending on how healthy you are. At 4-3/4-4, ideally you should 3* Galio and Soraka, with at least 2 completed items on each, as well as Lissandra 2 and Taric 2. If not, you should send it for those 2 units. You should then go 7 and roll for the following board:
Mid/Late game board
Late Game: Into Stage 5 you should have both Galio and Soraka 3*, as well as ideally Shen 2 and Sejuani 2. From here, you can decide to keep rerolling for Taric 3 and Lissandra 3 if you have 6+ units, or you can go 8 for a variety of boards. Some (only level 8 boards, you can use your creativity to figure out level 9 boards, don't want to make this guide too long) of the boards possible are shown below (There are an infinite number of playable variants, due to +1s):
Can sub Ryze with Karma/Cass

Way better with Targon +1 for 4 Targon

Sion variant for more CC

Donger variant for further CC
Additional Notes: K'Sante is the biggest counter to this comp, PLACE GALIO/TARIC ON THE OTHER SIDE OF THE BOARD AND SORAKA AWAY FROM THE KICK.

Final Notes

Sorry for the long post and have fun playing this degen comp. If played correctly, you should easily tempo stages 3-5 and cruise to an easy top 4. Enjoy it while invokers are still untouched :-)
submitted by DiorrTFT to CompetitiveTFT [link] [comments]

2023.06.06 14:55 SINTAX___ Finisher TTK

I want the fastest finisher in d2. Or are they all the same? Is it the choreography? Is it flow or synergy?
I bought the “swing of the scythe” it literally drags out the emote. Not impressed.
Finishers are considered Cosmetics Some I’m trying later today. Sure Shot Gladiators BladeRush Ionic Spear
submitted by SINTAX___ to DestinyTheGame [link] [comments]

2023.06.06 08:57 Wild_Statement_3112 Do you know radicals?

Do you know radicals?
radicals, also called "radicals" in chemistry, refer to atoms or groups with unpaired electrons formed by the splitting of covalent bond of molecules of compounds under external conditions such as light and heat. The seizure of electrons in human cells is the source of all diseases. Free radical ROS is a substance that lacks electrons (unsaturated electron substances), and after entering the human body, it competes for electrons everywhere. If the electrons of cell protein molecules are taken away, the protein will undergo alkylation by connecting with branched chains, forming distorted molecules and causing cancer.
In short, the basic reason for aging is that the electrons in human cells are robbed. In addition to the age factor, the main reason for aging, physical decline, and skin loss of luster and elasticity is that there are too many radicals in the body.
Where do 'radicals' come from?
External reasons:
Smoking and drinking, excessive exercise, ultraviolet radiation, electronic radiation, chemical pollution, life stress, food additives, excessive medication Irregular sleep patterns and residual cosmetics
Internal reasons:
The normal metabolism of the human body requires the consumption of oxygen, which is itself an oxidation process, and radicals are byproducts of metabolism.
The hazards of 'radicals'
  1. Skin aging, collagen will react under the action of radicals, resulting in insufficient nutrition for the skin Nourishing supply, causing a decrease in skin tissue vitality, loss of elasticity, wrinkles, and overall skin damage Aging, dull skin tone, etc
  2. Damage to cell membrane: radicals have extremely active reactivity, enhance lipid peroxidation, change the lipid microenvironment of membrane receptors, membrane proteases and ion channels, cause dysfunction, and damage the basic characteristics of the membrane;
3.Damage to proteins and genes, affecting functional expression or causing cell mutations;
  1. Destroy the molecular structure of tissue and gradually expand to cause functional damage;
  2. As age increases and radicals increase, the degree of red radicals corroding protein and lipid cells in the body also deepens, and the accumulation of lipid brown purple increases, leading to the gradual formation and appearance of color spots.
How can the eyes resist oxidation?
Antioxidation is the fight against radicals, and the eyes are one of the most vulnerable parts of our skin, as well as the most age sensitive area. Due to daily eye frequency and weak skin, the first area of aging on the entire face is around the eyes. Here is a recommended product specifically designed for eye oxygen supplementation, VIICode Oxygen Eye Cream. It contains skincare ingredients that target antioxidants, and long-term use will increase the antioxidant capacity of the eyes.
submitted by Wild_Statement_3112 to u/Wild_Statement_3112 [link] [comments]

2023.06.05 23:14 Holiday_Wing_7992 Beyond the Rothschilds: Who Really Rules the World and Why

To be transparent with you, I do not subscribe to any particular belief system. Like most of us here, I am engaged in an honest quest for truth and I am always prepared to admit I am wrong if the evidence demands it. I believe that a truth is to be found among all religions, and that the truth can indeed be found. When envisioning the structure of global authority, I like to picture it as a web of control, but the pyramid of power concept works just as well. So who is the spider at the centre of this web and what are their plans?
The outer rings of the web, as we all know, are things like educational institutions, the media, governmental departments etc. Move in to the centre a touch and we hit large corporations and their lobbyists. Move further into the web and we encounter think tanks and supranational organisations like the IMF, the Trilateral Commission, the Club of Rome (all roads lead there), the Bilderberg Group etc. Secret societies also, such as the Rosicrucians and Freemasons. Then we move in more and we find bloodlines such as the House of Rothschild, the Rockefellers etc. This is usually where things reach a dead end. However, few people realise that families such as the Rothschilds, Rockefellers, Duponts etc. are greatly overshadowed by far more ancient and prestigious bloodlines.
Move another ring into the centre of the web and we see the papal bloodlines. The black nobility. The Venetian cult that Kubrick warned us about in Eyes Wide Shut. Of course, the Rothschilds are of the same blood, but their branch is comparatively low level within the mafia-like structure. It's one big family with no mudbloods or muggles allowed. And I mean that quite literally, in the magical sense. Wherever there is trouble, they are there: Babylon, Nineveh, Tyre, Canaan, Kazharia, you name it. As for the spider in the middle, the closest you'll get are royal houses like Aldobrandini, Colonna, Orsini, Hanover, Guelph, Farnese etc. These are the families who control the Holy See which controls the Vatican. These are the families behind every pope, cardinal, and monarch of the past 2,000 years. The Orsini family alone claim 5 popes and 34 cardinals. And that rebel Martin Luther? He was shielded by the House of Wettin. Just another gang still going strong. For those interested in more, the Almanach de Gotha is the go-to source for the historical lineage of the dynasties that control this world.
In short, the monarchies of old are still in power and the Roman Empire is alive and well. But why do they rule over us? Pay close attention and you will see that the Colonna coat of arms is an Ionic pillar. This is the central pillar of Freemasonry, the synthesis of the masculine/solar Doric pillar and the feminine/lunar Corinthian pillar. It is the pillar of Wisdom. This is a key clue as to why royalty are the true rulers. It is crucial to understand that the royal households who rule over us believe they have a divine right to rule based on their blood. They are Anunnaki/fallen angel/watcheDagon/Oannes offspring. Anunnaki literally means 'princely offspring'. Our rulers descend from the ancient priest class who came from the stars and endowed Pre-Adamic man with Wisdom, Prudence, Foresight, and Reason. One only needs to watch 2001: A Space Oddyssey to see how this played out.
'Let these be guidestones to an age of Reason' - Georgia Guidestones
'Wisdom and Knowledge shall be the stability of thy times' - Rockefeller Centre Main Entrance
'Do what thou wilt shall be the whole of the law' - Alester Crowley
The term 'sapiens', as in modern day homo sapiens, means 'wise'. The deities from which our royal rulers descend were the fish men of Mesopotamia who emerged from the spiritual waters above and taught the secrets of the heavens. See the Book of Enoch for more. They are the Kings of old, the men of renown, who ruled before the flood. They remade man in their own image, after their own likeness, and some proceeded to live among us. The spirit of the nephilim still wanders the earth to this day, in the form of royalty and priesthood. That's why the Pope wears the Dagan fish hat. It is why we call them 'elites'. The prefix 'el' means Holy, hence the etymology of the angELs: MichaEL, UriEL, GabriEL, RaphaEL, AzazEL etc. There is a war between them, of course. Between the Sons of Light and the Sons of Darkness as they are described in the Dead Sea Scrolls.
So far I have identified who I believe rules the world and why they claim a divine right to rule. But what are their plans and how can we see them in action today? It is prophecised that the End of the Age/The New Atlantis (see Eschatology) will occur when the Davidic line is finally re-established in Jerusalem, where Solomon was anointed by Zadok. So it is written in the ancient Zadokite Fragments. This is why the Israeli flag has the so-called Star of David on it. This is why the Rothschild family are named after the Red Shield of David. It is why Zadok the Priest by Handel rang out when the King was anointed a month ago with a sacred oil consecrated by Rabbis in Jerusalem. With this understanding, scenes like this make the hairs on the back of your neck stand on end:
All this was preceded by the Archbishop of Canterbury (the city where I go to work, just a few miles from my home) celebrating the coming establishment of a 'Royal priesthood and a holy nation'. Holding his sceptre, Charles III literally became the next incarnation of the Davidic line. In the words of the Biblical Jacob himself: 'The Sceptre shall never depart from Judah until the Messiah comes'. They continue to await their Messiah. Why else do you suppose every Pope and President dons the skullcap and visits the Western Wall at the foot of Mount Zion? And let me be clear: anti-Zionism is NOT anti-Semitism. The world's first Zionest Conference was changed from Munich to Basel due to fhe sheer number of anti-Zionist Jewish protestors. They wanted no part in it. In the 1930s the Nazis tried desperately to solve the Jewish question (fulfill prophecy). They signed the Havaara Agreement with the Zionists allowing safe passage for Jews to Palestine. I did a three year history degree with a particular focus on Nazi Germany and had never heard of it before diving down the rabbit hole. The problem for the Zionists was that most German Jews were deeply embedded within German society and they didn't want to move to a dust bowl called Palestine. By 1948, after much maneuvering, the Zionist dream came true. It is no irony that Holocaust literally means 'burnt offering'. This was the Final Solution to the Jewish Question. The Jewish journalist Barry Chamish is excellent for truth on how the Jews are pawns in the hands of the Zionists. He paid the ultimate price for that.
Throughout his coronation, Charles sat upon the Stone of Destiny, the Rock of Ages, symbolising the stone that was given by 'God' to Jacob and was prophecised to be handed around among his kingly descendants. The Stone upon which Jacob had his dream and from which he hew a pillar on the very same spot upon which Solomon built his temple. Only to see his temple destroyed on the 9th day of the 11th month. The Second Temple was also destroyed on the 9th day of the 11th month. Known as Tisha Bav, the 9th day of the 11th month has always been a day of mourning in the Jewish calendar. After September 11th, they hew a pillar in the place of the twin towers. Part of the memorial was constructed by the Rock of Ages granite company. Truly, it is mind blowing. And the symbolism was written throughout the entire coronation ritual. But who will be installed as monarch in Jerusalem as Plato's Philosopher King, and when? I don't know. I have a feeling, though, that it will be timed in accordance with the positioning of the great universal sky clock, based as it is around the 'chief watcher of the heavens' in Plutarch's words, the Star of the Magi, Sirius (see my post '10 Crazy Facts About the God Star Sirius' for more).
Despite their notoriety, the Rothschilds, Rockefellers, and other more recent families are minions in comparison to other bloodlines. Although, the Rothschilds did marry into the Aldobrandini bloodline through Olimpia Aldobrandini and David Rothschild. You could of course take it a step further to the centre of the web, but then you're dealing with the archontic forces I have mentioned - not all of them negative - that exist in other realms and express themselves through the stars and planets. Towering over all of creation, the Demiurge, the grand architect of this maya, or illusion, in which we dream. The god who sought to impose his sense of order upon primordial chaos. Always manipulating, never creating. Finally, we arrive at the apex of the pyramid; the father, the monad, the eternally tranquil one from which the antagonistic two came into being.
submitted by Holiday_Wing_7992 to conspiracy_commons [link] [comments]

2023.06.05 22:00 Ethan-Wakefield ELI5: How can metals be so strong, when metallic bonds are generally weaker than ionic or covalent bonds?

submitted by Ethan-Wakefield to explainlikeimfive [link] [comments]

2023.06.05 16:18 BigTute Phase 1 Cancer Trail in China

These trials last up to ten years.
Phase 1 is for discerning toxicity and dosage.

Link to PR
CHICAGO, June 05, 2023 (GLOBE NEWSWIRE) -- Shanghai Escugen Biotechnology Co., Ltd. (“Escugen”), a partner of Levena (Suzhou) Biopharma Co., Ltd. (“Levena”), a wholly owned subsidiary of Sorrento Therapeutics, Inc. (Sorrento), today released preliminary results from a first-in-human study of ESG401, a trophoblast cell-surface antigen 2 (TROP2) antibody drug conjugate (ADC), in patients with locally advanced/metastatic solid tumors at the 2023 Annual Meeting of ASCO, the American Society of Clinical Oncology, held June 2-6 in Chicago, IL. ESG401 is an innovative ADC developed by Escugen and Levena. Escugen and Levena Biopharma jointly own the domestic and international patents of this ADC and share global rights for the product. ESG401 is composed of a humanized anti-Trop2 IgG1 monoclonal antibody (mAb) conjugated to a topoisomerase I inhibitor SN38 via a proprietary stable covalent linker with a drug antibody ratio (DAR) of 8. ESG401 has potential differentiated advantages over its competitors in terms of safety, effectiveness and process robustness. Using an innovative, highly stable and cleavable linker, this ADC demonstrated that it releases very little free toxin during circulation, which may reduce off target toxicity in a series of preclinical studies. Additionally, premature release of the mAb may compete for binding sites with the ADC to reduce its efficacy. The ADC highly enriches in tumor tissues and rapidly endocytoses, thereby effectively killing tumor cells and inhibiting tumor growth.
In the Phase I study, adult ESG401 patients with locally advanced/metastatic solid tumors refractory to or relapsed from standard treatments with measurable disease (RECIST v1.1) were eligible. ESG401 was administered by IV infusion initially in an ascending dose safety study by designated dose and regimen until unacceptable toxicity or progressive disease and followed by expansion cohorts. The Bayesian Optimal Interval (BOIN) design was used to establish the maximum tolerated dose (MTD). As of February 3, 2023, 35 heavily pretreated patients with a median age of 53 years were treated with at least one dose of ESG401 during dose escalation, 2 to 20 mg/kg administered every 3 weeks (Regimen A), or 12 to 16 mg/kg on day 1, 8, and 15 in a 4-week cycle (Regimen B). Eighty percent of the patients had an ECOG status of 1. Sixty-three percent of the patients had received at least 3 lines of prior therapy and overall the number of lines of prior therapy was a median of 4 (range 2-10). A total of 94% of patients had visceral metastases (11% brain, 63% liver, 60% lung) at baseline. From the ASCO poster, patient demographics and baseline characteristics is shown below:
submitted by BigTute to Open_Debate_SRNE [link] [comments]

2023.06.05 09:46 Myrrhmyrrha [PBE] "Popcorn" (Poppy/Taliyah Knockup Reroll) Guide

What the hell is popcorn? It’s just a fun name I chose for Poppy + Taliyah reroll. s/o u/snek_ens for coming up with the name Poprocks instead - that makes so much more sense and I'd rather call it that now.
Honestly, this comp is easily the most fun I’ve had with PBE so far because of how absurd it is, but I wanted to share with y’all what I think seems most optimal after quite a few games with it!I also do think that comps like these are kind of indicators of Legend strength, as Caitlyn seems so good for making this composition not only work, but feel extremely consistent in terms of how often you hit your units.
Poppy is super contested as of now but if you want to have some fun, I’d highly suggest having some popcorn before they nerf this one.
I don’t know who let me cook since I’m just some washed Masters elo player turned Double Up Diamond player who discovered this with a bunch of friends who hover Dia/Masters as well, but I do think this has seen some traction based on Reddit comments I’ve seen across a few threads, so I just wanted to make a post about it, ‘cause why not!
TL:DR if you wanna go forst:
Slowroll Lv5 for Poppy and pick up Taliyah and TeemoSlowroll Lv6 for Taliyah and Teemo after hitting Poppy 3Rush Lv8, add Heimer, Jarvan+Azir, K’SantePoppy Items BV/GaST/PV/RedempTaliyah Items JG/DCap/HoJ
Alright, so, here’s the long version.
Legend, Augments, Opener
  1. Realistically, I don’t know HOW impactful having a good legend here is, but I do think that Caitlyn helps a TON with ensuring you hit your units without falling too far behind on gold thanks to her Stars are Born and Rolling for Days augments saving you plenty of gold on rerolls. I’m certain that Lee Sin would probably be quite good too, but I haven’t tried it, so I cannot vouch for it. EDIT: Got some feedback on Lee Sin being stronger mathematically and that makes objective sense to me so I'm adjusting this to highly encourage Lee rather than Cait.
  2. Damage augments in the event you don’t hit good augments for reroll are a great way to keep you in the game, and late-game if you manage to find an XP augment after finding your 3* units, it can help to rush you to 8 so you can have a better shot at finding Heimer and the 4-cost units, which are crucial for winning out later.
  3. Honestly, if you don’t have a Poppy 2* by Krugs it is chalked, I’d move on. Otherwise, you can keep going, but Poppy is extremely crucial - if you manage to have 5 Poppys by the start of Stage 3, you’re comfy.
  1. Most high roll items I’ve seen are JG+HoJ - the crit damage increase you get with the additional HoJ is amazing and is a good way to neutralize an tear because Taliyah does not want mana items. Shiv on Teemo is super strong and probably BIS, and Poppy should be prioritized with tank items - Bramble and Gargoyle are the most important - 3rd slot can be anything from Redemption to Protector’s. Leftovers can go to Heimer, and one to Teemo (you don’t want to make Teemo the prioritized Yordle).
  2. EDIT: Warmog's should be in S tier as well, it's insanely strong w/ Bastion and I overlooked it - ran into a lot of AD lobbies when playing this which is why I recommended BV but u/AkinoRyuo made a good comment about Freljord, which makes Bramble not feel great in lobbies with that trait prevalent (and honestly I feel like Freljord is super strong so it's quite common, especially with AD comps). PV and Redemption can move up, GaSt can move down. Blue in a 4 Multicaster version according to AkinoRyuo seems good too.
  3. I’ve put an item tier list below for what I think felt best with the comp, but I also don't have a large sample size:
Tank items are for Poppy, Dmg items for Taliyah. Shiv/Ionic for neither, just Teemo and other frontliners for the Shred for Taliyah.
Early Game
  1. Most ideal level 5 board is Poppy, Taliyah, Teemo, Swain, and Kassadin - frontline and backline are extremely strong with this core 4, but if you can’t find a Kassadin, you can also stick in a Maokai or Swain, or even 3 Demacia and drop the Teemo/Taliyah for a Sona if you manage to get those more expensive units. You can also grab the Taric/Soraka Targon pair if you really don’t find any of the above units, but I’d transition towards those units as soon as you can.
  2. You are rolling at Lvl5 to start, picking up Poppy units as you see them, alongside Taliyah and Teemo. Prioritize picking up Kassadin and Swain as well for the 2* versions, but don’t tunnel on them unless you are finding a lot (sacrifice going for Teemo 3* and prioritize one of those two instead). EDIT: Maokai seems like a good option to roll for too instead of the 2cost 3* units while you roll for Poppy, s/o to u/DarthNoob for the comment on this which has more detail!
Ideal Lv5 board
Mid Game
  1. Once you hit Poppy 3*, you should chill above 50 gold at level 6 and slowroll for Taliyah and whatever other 2-cost unit you are accumulating (Teemo is most optimal). Yordles only requires 3 total 3stars, and they don’t have to be exclusively Yordles, so as long as you have Taliyah and Poppy 3*, you can scale toward endgame easily.
  2. Rush Lvl8 as soon as you can - you’re looking to add one of the 4cost strategists at 7 and the other at 8. Jarvan is BIS, so if you can manage to find that god of a unit and an Azir at the same time, slot in Jarvan first. Lvl8 should look like this:
  3. In some cases, you might not be able to find K’Sante, so you can keep Kassadin, or opt for a few other variations that include Sion or even Ryze depending on the game’s region, or another Jarvan.
  4. If you don’t have a Heimer, play Kled. Never play Tristana, that unit is fake.
Ideal Lv8 board
Late Game
  1. To win out, the most important piece is Heimer. The upgrades that are best are double Shrink + Mechano-Swarm, but dropping a Shrink for a Goldinator if you are behind and you manage to find a Heimer early can help to coddle you into late. The shrink applies additional shred that your Shiv may lack, especially if your Teemo manages to die - and the damage helps your Taliyah essentially 1-shot whoever Poppy wishes to knock up first.
  2. If you manage to hit this, you are probably going first unless someone in your lobby took Verdant Veil. Go next fast if that happens, I guess.
TFT PBE lobby quality is obviously iffy and some of these people died so damn early, but considering the final board was a Piltover cashout with a full board of Radiant items and the fight at the end wasn’t even close, I do think there is genuinely consistent 1st place potential with this board if you manage to grab everything. Watching the Aatrox pop was a sight to see.
And that’s it! I promise it’s a ton of fun and I’m sure I’m not the first one to play this but thanks to my friends in the screenshot I was able to theory out how to make this as consistent as possible and so far out of 8 games we have an 87.5% top4 rate with 2 wins and 1 fifth place finish. I don't know how to pull a TFT match history on PBE, so I hope that is enough to suffice for the guide. I hope you enjoy it before this Poppy unit gets gutted, probably. Thanks for reading!!
link to lolchess:
submitted by Myrrhmyrrha to CompetitiveTFT [link] [comments]

2023.06.05 04:18 Zealousideal-Luck553 Hair dryer ideas??

Hello! I’m in need of a new hair dryer and after searching online for a while I’m a little overwhelmed! So hoping I can get some ideas here.
I almost certainly want ionic! Very protective with my hair so minimum heat damage is priority. But would also like one that’s quiet or at least not super loud.
Anybody have a favorite they use?? And what they like about it?
Thank you!!
submitted by Zealousideal-Luck553 to Hair [link] [comments]

2023.06.05 02:47 Zombie-In-Action Is WebSql dead for Cordova?

I have been assigned with a task of working on an ionic-cordova project. The Android platform for the project is working fine with web SQL, but when I open my iOS workspace file and build it in xcode, it shows up blank.
On checking the developer tools the HTML is fine but starter JS shows that WebSql has been deprecated. Other than switching over to SQLite or IndexedDB, is there no other alternative to make my old code work via some Cordova plugin or something? Is WebSql really out?
submitted by Zombie-In-Action to developersIndia [link] [comments]

2023.06.04 23:51 bluebloodstar Would be cool if broodweaver wasnt the only super in the game that comes with a passive

Would be a great way to make taking certain supers not feel like throwing. If you read the description of needlestorm thats where warlocks get the passive of perched threadlings from, it would be cool if something like chaos reach made it so ionic traces gave super energy or maybe equipping daybreak makes ignitions do more dmg wtc
submitted by bluebloodstar to DestinyTheGame [link] [comments]

2023.06.04 21:12 mbwerst Can anyone explain this UW Question to me

The explanation says that since it is a permanent change, it is not an enzyme (sounds like a trick question tbh). What about irreversible inhibitors? Don't they permanently inhibit an enzyme?
submitted by mbwerst to Mcat [link] [comments]

2023.06.04 04:43 hiplikehesse Question About My Daughter's Hair Dye

I hope I'm in the right sub. If not, please kindly point me to the right one.
My teenage daughter needed to turn her hair from purple hair to brown (both semi-permanent). I know nothing about hair dye. Her mom hasn't been as engaged in her life lately due to a toxic boyfriend, so I was on my own. The Sally beauty employee said she should use Chi Ionic Shine Shade with no other advcie. My daughter applied this (darkest brown).
Nothing happened.
It turns out, there are two other ingredients needed. The instructions were about as clear as mud and I just followed my daughter's lead who said she knew what she was doing (bad idea).
She left it on for a couple of hours thinking it had "worked." I had her wash it out with shampoo after I realized we needed the other ingredients and nothing happened.
I know it didn't work. She is worried it will damage her hair or cause problems (she has bad anxiety). I honestly have no idea. Can anyone tell me if this was a major problem? Will it create issues for her hair?
Thanks in advance!
submitted by hiplikehesse to Hair [link] [comments]

2023.06.04 03:21 legwel_advice 2023 Ioniq 5 Limited RWD or 2020 Tesla Model S Performance

I'm considering the Ionic 5 RWD limited bc of the longer range than the AWD. I think at least 300 mi range is what I'm comfortable with, considering I rented the SEL AWD on a road trip from SoCal to Phoenix.

Ioniq 5



Tesla Model S



submitted by legwel_advice to whatcarshouldIbuy [link] [comments]

2023.06.03 18:08 ManuelIgnacioM Need some help to make sure I understand the η3-C3H5 ligand

So, I'm studying coordination complexes, I don't have much problem with them but I don't see clearly what the η3-C3H5 ligand is.
From the answers the teacher gives us to see if we got it right, I guess it gives 4 electrons and have a negative charge on the ionic model. I think it might be just the anionic form of an allyl group, giving the lone pair of the carbon with no double bond, and the pair on the pi bond.
For example, in an exercise that asks us to guess how many CO ligands are in some complexes by assuming they follow the 18 electron rule, one complex to guess that confuses me is [(η3-C3H5)Cr(CO)n]2.
The answer gives that there are 4 CO, giving 8 electrons. Since I'm not sure of the charges of the different components of the complex, I use the covalent model, Cr got 6 electrons and the ligand in question would have 3 if my guess is right, since these kinds of anions are considered radicals on the covalent model. That makes 17 electrons total, and the electron left to make 18 I guess is shared by the other Cr atom on a simple bond, since there is no ligand that acts like a bridge. I'm not sure if my line of thinking is totally correct so that's why I'm posting this.
submitted by ManuelIgnacioM to chemhelp [link] [comments]

2023.06.03 16:48 Proletlariet Thirteenth Doctor

Respect the Doctor


"Bit of adrenaline, dash of outrage, and a hint of panic knitted my brain back together. I know exactly who I am. I'm the Doctor. Sorting out fair play across the universe. Now please. Get off this planet while you still have a choice."

So you've come to see my respect thread? mmmm I love respect threads. In fact, I invented them right after 4 slice toasters. So... where was I? Oh, that's right. Me. Doctor, the Doctor. I was born on this little planet on the Constellation of Kasterborous... or was I? Things get a bit complicated there... where I came from or who I am. I've been lots of people, some of them I don't even remember. The person reading this might be the Doctor too (?)... Anyway, back on point. The person who I am now is an easy-going travelehigh-speed engineebiscuit-lover. Me and my fam explore the universe in muh good old TARDIS, righting wrongs and chilling like there's no tomorrow (which is a possibility wink-wink). I'm happy to be your bezzie mate if you play nicely, but if not --- well, you'll get an idea if you keep reading. (scronch)

Source Key

Hover over a feat to view its source.
  • Doctor Who (2005) series # episode # = S#E#
  • Twice Upon A Time = TUAT
  • Resolution = R
  • Revolution of the Daleks = RotD
  • Eve of the Daleks = EotD
  • Legend of the Sea Devils = LotSD
  • The Power of the Doctor = PotD


Technological Aptitude
Understanding Technology
Using/Operating Technology
Building Technology
Modifying Technology
Disabling Technology
Repairing Technology
Persuasion, Trickery & Manipulation
Planning & Strategy
Miscellaneous Skills

Mental Abilities

Mental Resistance & Willpower
Mind Reading & Communication
Mind Manipulation
Sensing & Feeling

Physical Attributes

Speed & Agility
Time Lords can survive fatal injuries through the process of regeneration whereupon every cell in their body is rewritten, radically transforming their appearance and personality. This regeneration produced some interesting changes...
Miscellaneous Time Lord Biology


Get the full rundown of the TARDIS and Sonic Screwdriver in the comments

Psychic Paper
The psychic paper is a blank piece of paper that telepathically projects the Doctor's thoughts into the eyes of whom she presents it to.
Futuristic Technology
Mundane Items


"She was the universe."

submitted by Proletlariet to u/Proletlariet [link] [comments]

2023.06.03 14:15 Lord-Rambo Lightning/ionic storm

The lightning or ionic storm is my favorite power that Cole has & I wish it wasn’t unlocked at the end of the infamous 1 & 2
submitted by Lord-Rambo to infamous [link] [comments]

2023.06.02 23:20 code_hunter_cc ionic geolocation plugin error: "No provider for Geolocation"

I'm trying to use geolocation in my ionic2 hello world project, and I add the ionic plugin "Geolocation" following the instruction on the official site.
I've run these two commands:
$ ionic plugin add cordova-plugin-geolocation$ npm install --save @ionic-native/geolocation And this is my home.ts:
import { Component } from '@angulacore';import {Geolocation} from '@ionic-native/geolocation'import { NavController } from 'ionic-angular';@Component({ selector: 'page-home', templateUrl: 'home.html'})export class HomePage { map:any=null; geoInfo:any={ resp:'', data:'' }; constructor( public navCtrl: NavController, private geolocation: Geolocation ) { } test(){ this.geolocation.getCurrentPosition().then((resp) => { this.geoInfo.resp=JSON.stringify(resp); // resp.coords.latitude // resp.coords.longitude }).catch((error) => { console.log('Error getting location', error); this.geoInfo.resp='Error getting location'; }); let watch = this.geolocation.watchPosition(); watch.subscribe((data) => {; // data can be a set of coordinates, or an error (if an error occurred). // data.coords.latitude // data.coords.longitude }); }} However, I got the following error in my chrome's console:
EXCEPTION: Error in ./TabsPage class TabsPage - inline template:0:0 caused by: No provider for Geolocation!error_handler.js:56ORIGINAL EXCEPTION: No provider for Geolocation! ![screenshot](
At first I thought it was because I was debugging in browser, but then I got then same error in my Android phone.
So what does "No provider for Geolocation" mean and how should I use geolocation in my ionic2 project?
Thanks a lot!
Answer link :
submitted by code_hunter_cc to codehunter [link] [comments]

2023.06.02 19:40 Specific-College-194 how to solve? explanation pls

how to solve? explanation pls submitted by Specific-College-194 to igcse [link] [comments]

2023.06.02 19:02 CourtRooom Comprehensive Breakdown & Infographic of Rocket Launcher Frames - Updated for Season 21

We went from zero Rockets in Season 20, to 3 (4 if you count the Solstice Strand one but I'll omit it in this breakdown) in Season 21 - so of course I am back with an updated breakdown of Rocket Launchers for Season of the Deep.
Lots have changed and moved about, including a Mid-Season Update in S20 that tweaked with the Reserve Mods, so I'll be concentrating on those big highlights. If you're wanting a refresher on Rocket Launchers: see this S20 post and my original post too. As a note: those were written up in S20 and S19 respectively, but the core breakdown will still apply. I make these seasonal updates just to highlight any changes, additions, and more.
I also come with an updated Infographic. Once again this is split into two parts; part one highlights individual Rockets, where to get them, their frames, and damage profiles, whereas part two is focused on Perks and Ammo.
This is another Comprehensive Breakdown in my long series of these posts.
Previous Breakdowns
You can also find me in the Destiny Massive Breakdowns community including the MB:PvE Podcast and MB Discord server, and I post various Destiny informative guides and graphics on my Twitter too.
Edits: if there are any I'll post any subsequent edits/clarifications at the bottom of this post.

Seasonal Reminder

This post is written in the perspective of Season 21 (Season of the Deep); if you are reading this in the future then please keep this in mind that some things may have changed, been added, or removed. I do these write-ups every Season and avoid editing legacy (older) breakdowns and write-ups, so it may be worth checking for the Season you are in.
As already mentioned I'll be focusing on new things, changes, and highlighting worthwhile data and information. Links to previous breakdowns posted in the intro of this post.
As a reminder, here's a quick recap of Rocket Launchers:


Season 21: New Rockets & Perks

New/Refreshed Rocket Launchers
These breakdowns are mainly objective, but I've added some perk highlights, those in bold are the things that caught my eye.
Exotic Weapons
No new fundamental changes here, but wanted to list one highlight.
Weapon Perks
Origin Traits
I don't normally do a write-up on Origin Traits, but considering the Ghosts of the Deep Dungeon has a really synergistic one I'll put on here.
Wolfpack Rounds
With new Perks we have new interactions with Wolfpack Rounds. This breakdown post is still pretty relevant re: Wolfpack Rounds by u/m4eix, but I'm adding an addendum to it:
So if you're wanting a new high-damage pairing for Wolfpack Rounds (which was formerly Explosive Light despite not even buffing them): go for Bait and Switch. Surrounded be doing weird things.

Season 21: Changes & Removals

Deepsight Harmonizer
Season 21 debuted the new "Deepsight Harmonizer" currency. This allows you to add Deepsight Resonance ("red box") so you can make progression on being able to craft it. This TWAB goes into more detail including restrictions, but basically older weapons with no direct source like Bump in the Night can now be crafted after utilising this currency; Bump in the Night itself can drop from the Gunsmith or Xur. They can also be used for those weapons that still have direct ways to acquire them (e.g. Red Herring and Apex Predator).
Unobtainable Rockets
Bump in the Night is still not directly acquirable (outside of XuGunsmith, which can be purchased and can RNG drop as a Deepsight version, or Deepsight can be applied to it) and joins the following Rockets that are not sunset but have no direct acquisition method (excluding XuGunsmith):
Changes to Reserve Mods
I attached an addendum to my previous S20 post with information related to the Mid-Season Update that changed Reserve Mods. I'll highlight it here, along with some additional information:
Reserve Mods were changed in Update 7.0.5. In general this didn't really make too much of a change to Rocket Launchers, but it did help out a few. Reminder: Reserve Mods adds to the 'Inventory Size' stat, which I'll go into more detail later.
For context, the following Rockets benefited from these changes (total ammo capacity; magazine+reserves):
In terms of ammo economy: the big highlight here is Hezen Vengeance. You'll still have more efficient and generally higher reserve pools with Enhanced Field Prep Red Herring and Bump in the Night, but Hezen being able to hit 10 makes it one of the best high-damage non-Field Prep Rockets, even beating out the now juiced Apex Predator (which I suppose offsets this by having an amazing perk pool).
If you want a partial list of how this affects most Rockets (craftable, recent, and community highlights) see Part II of the infographic. For a complete list, I've updated my spreadsheet page ("Rocket Launchers Overview" Tab) to include them all + interactions with various ammo Perks.

Supplementary Information

Rocket Launcher Total Ammo Capacity
It wouldn't be a Court Rocket Launcher Breakdown post if I didn't highlight Inventory Size stat again and again. Haha, but in all seriousness this isn't going to be as dense as previous posts but I did want to reiterate some points.
Ammo Capacity (amongst other things but they aren't in the scope of this breakdown) is affected by the hidden "Inventory Size" stat. The higher this stat is, the more ammo you can carry - for Rocket Launchers this is pretty easy to calculate as you're working with small numbers. It also affects how much ammo you gain when you pick up a standard ammo brick, which I'll summarise here:
I will once again defer to MossyMax who has done huge work in ammo capacity for all weapons and exhaustive testing on this stat.
To calculate how much total ammo capacity (again, credit to MossyMax who deciphered this formula) as being the following (numbers always round up):
( ( [RL Inventory Size base number] * 0.05 ) + 4.5 ) = total ammo capacity
e.g. Sleepless has a base Inventory Size stat of 36
((36 * 0.05) + 4.5) = 7 total ammo capacity
For those curious: you can find the Inventory Size stats on websites that relay and utilise the game's API (such as
Here's how the new/refreshed Rockets fair with the total ammo capacity (magazine+reserves) with no additional perks (Bipod is listed further down):
Base Base Total Ammo Capacity w/ 1x Reserves w/ 2x Reserves w/ 3x Reserves
Apex Predator 7 8 9 9
BrayTech Osprey 7 8 9 9
Cold Comfort 7 8 9 10
BrayTech Osprey w/ Field Prep 8 9 10 10
Cold Comfort gets 10 total ammo capacity because it has a high Inventory Size stat of 45 so can breach that next breakpoint (for those wondering that's over 40). BrayTech Osprey is the only one out of the three to get Field Prep.

Rocket Launchers Can Get More Than 10
Rocket Launchers are hard capped to 10... or so we thought anyway. While under normal circumstances Rockets cannot breach this cap, the new perk Bipod - and one of Ahsa's Empowerment buff in the Deep Dive activity - can go beyond this cap.
We'll focus on Bipod in this section. For the magazine it's a simple 2x of the base magazine, which can be stacked with Envious Assassin and Reconstruction's effects (Bipod increases base magazine first, then EA/Recon compounds on that number).
Envious Assassin Magazine Size
Reconstruction Magazine Size
When it comes to how Bipod and how much total ammo capacity (magazine+reserves), this is also pretty simple: it's a +5 to whatever the non-Bipod total ammo capacity. Credit to Mossy once again. Here's a table to quantify it:
w/ Bipod Base Total Ammo Capacity w/ 1x Reserves w/ 2x Reserves w/ 3x Reserves
Apex Predator 12 13 14 14
BrayTech Osprey 12 13 14 14
Cold Comfort 12 13 14 15
BrayTech Osprey w/ Field Prep 13 14 15 15 [16*]
Note: Perks like Envious Assassin and Reconstruction do not affect how many reserves you get. Osprey w/ Field Prep + Bipod data is all but confirmed, will revisit once we know for sure what 3x Reserves truly provides (\it could be 16 as standard Field Prep at 3x Reserves is technically 11 but the cap brings it down to 10).*

Post-Posting Edits Section
submitted by CourtRooom to DestinyTheGame [link] [comments]

2023.06.02 16:43 Imaginary-Paper-2497 Is the bond between cofactors and enzyme covalent or ionic?

I find it hard to believe it would be covalent as there are metal ions and non-metal ions.
submitted by Imaginary-Paper-2497 to ALevelBiology [link] [comments]

2023.06.02 09:02 rayQuGR Oasis + Covalent = sapphire data on web3!

For those not familiar, Oasis is a blockchain that aims to empower developers and users by providing privacy-preserving technology on the blockchain. Covalent, on the other hand, is a leading provider of indexing and querying solutions for Web3 data.
Now, with this partnership, we can expect to see even more transparency and accessibility in the decentralized world. Sapphire data will be a game-changer for developers.
Sapphire is the bomb when it comes to confidential EVM-compatible runtime on Oasis. developers can whip up on-chain dApps with smart contracts that are totally confidential, totally public, or somewhere in between. It's like having a secret handshake with the blockchain! You get to choose how much you want to spill the beans. Privacy meets creativity, my friends!
What are your thoughts on this partnership?
submitted by rayQuGR to Crypto_General [link] [comments]

2023.06.02 05:45 RegionDifficult7373 Why is A the correct answer for this?

Why is A the correct answer for this?
Title ^
I choose D as both of the sentences around the blank seem to me independent. I'm not sure though as the answer reflects only a comma.
submitted by RegionDifficult7373 to EnglishLearning [link] [comments]